The lip region is an extremely important area when it comes to facial aesthetic enhancement. The lips have since time immemorial been highlighted along with the eyes as the two most beautiful regions of a woman's or a man's face. With the passage of time, photo damage, hereditary factors, and smoking contribute to loss of lip volume, peri oral rhytides, and prominence of mentolabial folds. Genetically thin lips and cosmetic asymmetries of the lips are also issues that can be dealt with similarly, that is, by soft tissue augmentations using fillers. Successful rejuvenation of the perioral region requires sophistication in using a combination of technologies and injectables.